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Biostatistician III
Harvard University T.H. Chan School of Public Health
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Biostatistician III

Harvard University T.H. Chan School of Public Health

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Details
Posted:
November 21, 2020
Location:
USA - MA - Boston
Salary:
Open
Type:
Full-time
The Center for Biostatistics in AIDS Research (CBAR), an organization within the Harvard T.H. Chan School of Public Health, is responsible for the design, monitoring and statistical analysis of clinical trials and observational studies for several major national and international NIH-funded clinical research networks. CBAR employs over 100 statisticians and epidemiologists including Harvard faculty, research scientists, and staff. Investigators within CBAR have provided statistical leadership and support for clinical research networks for more than 30 years. Currently this includes infectious disease networks such as: the Adult AIDS Clinical Trials Groups (ACTG), the International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT), and the Pediatric HIV/AIDS Cohort Study (PHACS). Results from studies have helped to establish the paradigm for the treatment and prevention of HIV and other infectious diseases, and contributed to international treatment and prevention guidelines.

CBAR is looking to hire a Biostatistician III to act as a senior statistician, collaborating directly with medical researchers in the design, implementation, analysis and publication of Phase I through Phase IV clinical trials, diagnostic studies and observational studies. This position will also serve on internal committees. The primary focus initially will be on studies undertaken by the AIDS Clinical Trials Group (ACTG) in the Tuberculosis Transformative Science Group (TB TSG). The TB TSG is responsible for development, implementation, and oversight of the ACTG research agenda related to the treatment and prevention of TB with and without HIV co-infection.

The primary objectives of the TB TSG are to:
  • Develop shorter, safer treatment regimens for drug-susceptible and resistant TB disease
  • Identify optimal TB preventive therapy for drug-susceptible latent TB infection and household contacts exposed to multi-drug resistant TB
  • Identify regimens for the treatment of TB meningitis and isoniazid-monoresistant TB (areas of high unmet medical need)
  • Evaluate TB vaccine immunogenicity and use in the prevention of TB infection and recurrence in adults
  • Optimize TB treatment and prevention in TB/HIV co-infected people
Additional aims include conducting transformative research to:
  • Describe drug-drug interactions involving anti-TB therapy and ART
  • Improve TB diagnostic assays and biomarkers to predict and detect disease and to monitor response to therapy
  • Develop novel TB clinical trial designs
Duties and responsibilities include, but are not limited to, the following:
  • Provide expertise as a senior statistician; Collaborate independently with the medical researchers of the ACTG in the design, conduct, analyses, and publication of national and international clinical trials and other clinical studies;
  • Conduct ongoing, periodic and final analyses of data, using specialized statistical techniques and programming; Review proposed protocol and study methodology, and other related factors to ensure conformance with accepted statistical principles, recommending revisions and modifications;
  • Write statistical considerations for protocol documents and study proposals, according to appropriate statistical methods;
  • Oversee development of data collection forms and proposed data management methods to ensure that the data to be collected will meet study objectives and allow valid analyses;
  • Develop randomization and stratification materials in compliance with protocol design;
  • Ensure the integrity of data collection, review, compilation and analyses by monitoring protocols, databases, and procedures to enforce compliance with proper statistical techniques;
  • Collaborate with clinicians on manuscripts, abstracts and other publications documenting study findings. Develop and complete first author peer-reviewed manuscripts when requested;
  • Maintain professional knowledge and expertise as well as an awareness of emerging scientific areas;
  • Create and execute project work plans, revising as appropriate to meet changing needs and requirements;
  • Effectively apply methodology and enforces project standards;
  • Ensure project documents are complete, current, and stored appropriately;
  • Deliver engaging, informative, well-organized presentations.
Since 1989, CBAR and the Harvard T.H. Chan School of Public Health has provided a strong program for growth and development of its research staff - including a defined career path and opportunities for continuing education and attendance of professional meetings.

Please attach the following when applying: 1) Resume, 2) Cover letter, 3) Transcript (official or unofficial) from MA/MS program and 4) Names and email addresses for three (3) professional references.

PLEASE NOTE: This position has a term end date of November 30, 2027, with strong likelihood of extension.

PLEASE NOTE: The primary work location for this position is Boston, Massachusetts. Until our return to campus, which is still to-be-determined, this interview process and position will be conducted virtually – including virtual interviews, remote onboarding, and remote work. The remote nature of this position is only temporary. Local, on-campus work will be required once the School and this role return to an operational status that supports it.



  • Harvard University requires pre-employment reference checks and background screenings.
  • This position has a 120 day orientation and review period.
  • The Harvard T.H. Chan School of Public Health does not provide visa sponsorship for administrative and staff positions.
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The Harvard T.H. Chan of Public Health is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – including fostering respect for all, serving the greater good, and welcoming individuals from diverse backgrounds, experiences, and perspectives. To learn more about the Chan School's mission, objectives, and core values, please visit our website here.

Harvard offers an outstanding benefits package including:
  • Time Off: 3- 4 weeks paid vacation, paid holiday break, 12 paid sick days, 11.5 paid holidays, and 3 paid personal days per year.
  • Medical/Dental/Vision: We offer a variety of excellent medical plans, dental & vision plans, all coverage begins as of your start date.
  • Retirement: University-funded retirement plan with full vesting after 3 years of service.
  • Tuition Assistance Program: Competitive tuition assistance program, $40 per class at the Harvard Extension School and discounted options through participating Harvard grad schools.
  • Transportation: Harvard offers a 50% discounted MBTA pass as well as additional options to assist employees in their daily commute.
  • Wellness Options: Harvard offers programs and classes at little or no cost, including stress management, massages, nutrition, meditation and complimentary health services.
    Harvard access to athletic facilities, libraries, campus events and many discounts throughout metro Boston.
Join the Harvard T.H. Chan School of Public Health to support our mission of health research and education, and to be a part of the oldest institution of higher learning in the country!

Salary Grade: 058

Union: 00 - Non Union, Exempt or Temporary

  • Master's Degree in Biostatistics, Statistics, or a closely related field required
  • 5+ years of related experience required
  • Experience with statistical software (such as SAS, Stata, etc.) required
Please attach the following when applying: 1) Resume, 2) Cover letter, 3) Transcript (official or unofficial) from MA/MS program and 4) Names and email addresses for three (3) professional references.

  • Two-year MA/MS program preferred
  • Professional experience and/or education in statistical analysis or clinical or biological data, including failure time and categorical data, preferred
  • Specialized and highly technical knowledge of statistical design, monitoring, analysis, and reporting techniques in clinical research studies preferred
  • Understanding of statistical principles associated with clinical trials, categorical data, survival data, longitudinal data, and diagnostics studies preferred
  • Advanced computer skills and experience with major statistical computing packages preferred
  • Experience independently designing, conducting, monitoring, and analyzing data from clinical trials preferred
  • Experience independently preparing written reports and manuscripts for publication and summarizing study results preferred
  • Experience meeting deadlines and directing other staff, and experience with managing successful projects preferred
  • Experience with MS Office (Word, Excel, PowerPoint) preferred
  • Advanced SAS and R software skills preferred
  • Excellent oral and written communication skills with experience effectively collaborating with senior medical investigators and data managers preferred
  • Knowledge of medical terminology and medical research methods preferred


EQUAL OPPORTUNITY EMPLOYER: We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

Internal Number: 51712BR
About Harvard University T.H. Chan School of Public Health
Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders in many disciplines who make a difference globally. The University, which is based in Cambridge and Boston, Massachusetts, has an enrollment of over 20,000 degree candidates, including undergraduate, graduate, and professional students. Harvard has more than 360,000 alumni around the world. The University has twelve degree-granting Schools in addition to the Radcliffe Institute for Advanced Study, offering a truly global education. Established in 1636, Harvard is the oldest institution of higher education in the United States.
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